Best R-22 Replacement Refrigerants: Drop-In Options Explained
R-22 (HCFC-22) has been phased out — U.S. production and import of new R-22 ended January 1, 2020. If you maintain older air-conditioning or refrigeration equipment, here are the most common R-22 replacement refrigerants and how to choose one.
Why R-22 is gone
R-22 is an ozone-depleting HCFC. Under the Clean Air Act and the Montreal Protocol, its production and import were phased out. Only reclaimed or recycled R-22 remains legally available, and supply is limited and expensive. For most owners, switching to a replacement refrigerant is the practical path.
Common R-22 replacement refrigerants
R-407C
A long-standing R-22 retrofit for air conditioning. Capacity is close to R-22, but it typically requires changing to POE oil.
R-422B / NU-22B
A popular service replacement designed to work with the existing mineral oil in many systems, which simplifies retrofits.
R-438A (MO99)
Formulated to closely match R-22 performance across AC and refrigeration, often with minimal system changes.
R-407A & R-427A
Blends used for refrigeration and some AC retrofits, chosen for capacity and lower GWP than older options.
Quick comparison
| Refrigerant | Best for | Oil |
|---|---|---|
| R-407C | AC retrofits | POE |
| R-422B (NU-22B) | AC service swaps | Often mineral-compatible |
| R-438A (MO99) | AC & refrigeration | Mineral/POE |
| R-407A / R-427A | Refrigeration | POE |
How to choose
- Check the equipment: manufacturer guidance and the system’s design matter more than any single “best” refrigerant.
- Mind the oil: some replacements work with existing mineral oil; others need POE.
- Use a certified tech: retrofits should be performed by an EPA 608-certified technician.
Browse our legacy refrigerants for R-22 replacement options, or see all refrigerants.
Frequently asked questions
Can I still buy R-22?
Only reclaimed/recycled R-22 is available, and supply is limited and costly. New production and import ended in 2020.
Is there a true drop-in replacement for R-22?
Not exactly — replacements are retrofit refrigerants that usually require some system changes. “Drop-in” is used loosely in marketing.
Do I need EPA certification?
Yes — EPA Section 608 certification is generally required to purchase and handle these refrigerants.
Looking for an R-22 replacement?
NU-22B, MO99, R-407C and more — factory-sealed and ready to ship.
